Segmentation and volumetric measurement of renal cysts and parenchyma from MR images of polycystic kidneys using multi-spectral analysis method

K. T. Bae, P. K. Commean, B. S. Brunsden, D. A. Baumgarten, B. F. King, L. H. Wetzel, P. J. Kenney, A. B. Chapman, V. E. Torres, J. J. Grantham, L. M. Guay-Woodford, C. Tao, J. P. Miller, C. M. Meyers, W. M. Bennett

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


For segmentation and volume measurement of renal cysts and parenchyma from kidney MR images in subjects with autosomal dominant polycystic kidney disease (ADPKD), a semi-automated, multi-spectral anaylsis (MSA) method was developed and applied to T1- and T2-weighted MR images. In this method, renal cysts and parenchyma were characterized and segmented for their characteristic T1 and T2 signal intensity differences. The performance of the MSA segmentation method was tested on ADPKD phantoms and patients. Segmented renal cysts and parenchyma volumes were measured and compared with reference standard measurements by fluid displacement method in the phantoms and stereology and region-based thresholding methods in patients, respectively. As results, renal cysts and parenchyma were segmented successfully with the MSA method. The volume measurements obtained with MSA were in good agreement with the measurements by other segmentation methods for both phantoms and subjects. The MSA method, however, was more time-consuming than the other segmentation methods because it required pre-segmentation, image registration and tissue classification- determination steps.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008
Subtitle of host publicationImage Processing
StatePublished - May 19 2008
EventMedical Imaging 2008: Image Processing - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2008: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA


  • Cysts; kidney
  • Image segmentation
  • Kidney
  • MR
  • Multi-spectral analysis
  • Polycystic kidney disease

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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