Secondary Sclerosing Cholangitis. Pathogenesis, Diagnosis, and Management.

Mohamad H. Imam, Jayant A. Talwalkar, Keith D. Lindor

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Secondary sclerosing cholangitis (SSC) is an aggressive and rare disease with intricate pathogenesis and multiple causes. Understanding the specific cause underlying each case of SSC is crucial in the clinical management of the disease. Radiologic imaging can help diagnose SSC and hence institute management in a timely manner. Management may encompass simple interventions, such as supportive therapy, antibiotics, and monitoring, or more serious measures, such as surgery, endoscopic intervention, or liver transplantation. Patients with AIDS cholangiopathy have limited therapeutic options and worsened survival. The disease should always be highly suspected in patients with primary sclerosing cholangitis with questionable diagnosis.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalClinics in liver disease
Issue number2
StatePublished - May 2013


  • Cholangiopathy
  • Clinical management
  • Complications
  • Liver transplantation
  • Outcomes

ASJC Scopus subject areas

  • Hepatology


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