Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation

Takayuki Warisawa, Christopher M. Cook, Christopher Rajkumar, James P. Howard, Henry Seligman, Yousif Ahmad, Stephanie El Hajj, Shunichi Doi, Akihiro Nakajima, Masafumi Nakayama, Sonoka Goto, Rafael Vera-Urquiza, Takao Sato, Yuetsu Kikuta, Yoshiaki Kawase, Hidetaka Nishina, Ricardo Petraco, Rasha Al-Lamee, Sukhjinder Nijjer, Sayan SenSunao Nakamura, Amir Lerman, Hitoshi Matsuo, Darrel P. Francis, Yoshihiro J. Akashi, Javier Escaned, Justin E. Davies

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objectives: The aim of this study was to assess the long-term clinical outcomes of patients with left main coronary artery (LM) stenosis in whom treatment strategy was based on the instantaneous wave-free ratio (iFR). Background: The overall safety of iFR to guide revascularization decision making in patients with stable coronary artery disease has been established. However, no study has examined the safety of deferral of revascularization of LM disease on the basis of iFR. Methods: This multicenter observational study included 314 patients in whom LM stenosis was deferred (n = 163 [51.9%]) or revascularized (n = 151 [48.1%]) according to the iFR cutoff ≤0.89. The primary endpoint was a composite of all-cause death, nonfatal myocardial infarction, and ischemia-driven target lesion revascularization. The secondary endpoints were each individual component of the primary endpoint and also cardiac death. Results: At a median follow-up period of 30 months, the primary endpoint occurred in 15 patients (9.2%) in the deferred group and 22 patients (14.6%) in the revascularized group (hazard ratio: 1.45; 95% confidence interval: 0.75 to 2.81; p = 0.26), indicating no evidence of a significant difference between the 2 groups. For the secondary endpoints, findings in the iFR-based deferral and revascularization groups were as follows: all-cause death, 3.7% versus 4.6%; cardiac death, 1.2% versus 2.0%; nonfatal myocardial infarction, 2.5% versus 5.3%; and target lesion revascularization, 4.3% versus 5.3% (p > 0.05 for all). Conclusions: Deferral of revascularization of LM stenosis on the basis of iFR appears to be safe, with similar long-term outcomes to those in patients in whom LM revascularization was performed according to iFR values.

Original languageEnglish (US)
Pages (from-to)1655-1664
Number of pages10
JournalJACC: Cardiovascular Interventions
Issue number14
StatePublished - Jul 27 2020


  • coronary physiology
  • left main coronary artery disease
  • registry-based study
  • resting intracoronary index

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation'. Together they form a unique fingerprint.

Cite this