@inbook{547b6e2bd7664f46a92a3e69da286b95,
title = "RUNX3 and p53: How two tumor suppressors cooperate against oncogenic ras?",
abstract = "RUNX family members play pivotal roles in both normal development and neoplasia. In particular, RUNX1 and RUNX2 are essential for determination of the hematopoietic and osteogenic lineages, respectively. RUNX3 is involved in lineage determination of various types of epithelial cells. Analysis of mouse models and human cancer specimens revealed that RUNX3 acts as a tumor suppressor via multiple mechanisms. p53-related pathways play central roles in tumor suppression through the DNA damage response and oncogene surveillance, and RUNX3 is involved in both processes. In response to DNA damage, RUNX3 facilitates p53 phosphorylation by the ATM/ATR pathway and p53 acetylation by p300. When oncogenes are activated, RUNX3 induces ARF, thereby stabilizing p53. Here, we summarize the molecular mechanisms underlying the p53-mediated tumor-suppressor activity of RUNX3.",
keywords = "ARF, DNA damage, Oncogene surveillance, RUNX, Tumor suppressor, p53",
author = "Lee, {Jung Won} and {van Wijnen}, Andre and Bae, {Suk Chul}",
note = "Funding Information: S-C. Bae is supported by a Creative Research Grant (2014R1A3A2030690) through the National Research Foundation (NRF) of Korea and a Research Grant of Chungbuk National University (2014). J-W. Lee is supported by the Basic Science Research Program (2014R1A1A2007204) through the NRF funded by the Ministry of Education of Korea. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017.",
year = "2017",
doi = "10.1007/978-981-10-3233-2_20",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "321--332",
booktitle = "Advances in Experimental Medicine and Biology",
}