Role of Inferior Vena Cava Dynamics for Estimating Right Atrial Pressure in Congenital Heart Disease

Alexander C. Egbe, Heidi M. Connolly, Patricia A. Pellikka, Jason H. Anderson, William R. Miranda

Research output: Contribution to journalArticlepeer-review


Background: Inferior vena cava (IVC) size and collapsibility (IVC dynamics) are used for estimating right atrial pressure (RAP). However, the diagnostic performance of the American Society of Echocardiography IVC criteria for estimating RAP in patients with congenital heart disease are unknown. The purpose of this study was to assess the role of IVC dynamics for estimating RAP in adults with congenital heart disease. Methods: We conducted a retrospective study of adults with congenital heart disease that underwent cardiac catheterization and echocardiogram at Mayo Clinic (2003-2019). IVC diameter was measured at inspiration (IVCmin) and end-expiration (IVCmax), and IVC collapsibility index (IVCCI) was calculated. Results: Based on 918 patients, we observed a good correlation between IVCmaxand invasive RAP (r=0.56, P<0.001); IVCminand RAP (r=0.58, P<0.001); and IVCCI(r=-0.72, P<0.001). There was excellent correlation between invasive RAP and estimated RAP using IVCCI(r=0.80, P<0.001). We observed that IVCCI<60% had superior diagnostic performance as compared with American Society of Echocardiography criteria (IVCmax>2.1 cm, area under the curve difference 0.15, P<0.001; IVCCI<50%, area under the curve difference 0.09, P=0.008; combination of IVCmax>2.1 cm; and IVCCI<50%, area under the curve difference 0.06, P=0.02). Estimated RAP >10 mm Hg based on IVCCIhad comparable prognostic performance as invasive RAP but superior prognostic performance as the American Society of Echocardiography criteria. Conclusions: IVCCI<60% was the best criterion to identify patients with elevated RAP. IVCCIwas comparable to invasively measured RAP in its relation to prognosis. Further studies are required to determine whether the use of IVCCIin clinical decision-making will improve clinical outcomes in this population.

Original languageEnglish (US)
Pages (from-to)E014308
JournalCirculation: Cardiovascular Imaging
Issue number9
StatePublished - Sep 1 2022


  • atrial pressure
  • catheterization
  • diagnosis
  • heart failure
  • hypertension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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