TY - JOUR
T1 - Risk of incident chronic obstructive pulmonary disease in patients with rheumatoid arthritis
T2 - A systematic review and meta-analysis
AU - Ungprasert, Patompong
AU - Srivali, Narat
AU - Cheungpasitporn, Wisit
AU - Davis, John Manley III
PY - 2015
Y1 - 2015
N2 - Objective: To investigate the risk of subsequent development of chronic obstructive pulmonary disease (COPD) in patients with rheumatoid arthritis (RA). Methods: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio or standardized incidence ratio with 95% confidence interval (CI), comparing risk of incident COPD in patients with RA versus non-RA participants. Pooled risk ratio and 95% CI were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Four retrospective cohort studies with 32,675 patients with RA and 122,204 controls were included in the data analysis. The pooled risk ratio of incident COPD in patients with RA versus control was 1.99 (95% CI, 1.61-2.45). The statistical heterogeneity was high with an I2 of 81%. Conclusion: Our study demonstrated a statistically significant increased risk of subsequent development of COPD among patients with RA.
AB - Objective: To investigate the risk of subsequent development of chronic obstructive pulmonary disease (COPD) in patients with rheumatoid arthritis (RA). Methods: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio or standardized incidence ratio with 95% confidence interval (CI), comparing risk of incident COPD in patients with RA versus non-RA participants. Pooled risk ratio and 95% CI were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Four retrospective cohort studies with 32,675 patients with RA and 122,204 controls were included in the data analysis. The pooled risk ratio of incident COPD in patients with RA versus control was 1.99 (95% CI, 1.61-2.45). The statistical heterogeneity was high with an I2 of 81%. Conclusion: Our study demonstrated a statistically significant increased risk of subsequent development of COPD among patients with RA.
KW - COPD
KW - Epidemiology
KW - Meta-analysis
KW - Rheumatoid arthritis
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U2 - 10.1016/j.jbspin.2015.05.016
DO - 10.1016/j.jbspin.2015.05.016
M3 - Article
C2 - 26709254
AN - SCOPUS:84950112926
SN - 1297-319X
JO - Joint Bone Spine
JF - Joint Bone Spine
ER -