Risk of cancer among relatives of patients with glioma

Brian P. O’Neill, Hannes Blondal, Ping Yang, Gurri H. Olafsdottir, H. Sigvaldason, Robert B. Jenkins, David W. Kimmel, Bernd W. Scheithauer, Walter A. Rocca, Johannes Bjornsson, Hfran Tulinius

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We report a population-based, retrospective study of 396 Icelandic people diagnosed with glioma in the years 1940-1995. The purpose of this study was to test whether astrocytomas, other glial tumors, other central nervous system tumors, or other cancers aggregate in families identified through glioma probands who were of Icelandic origin. Pedigrees of the 396 cases were traced by the Genetical Committee of the University of Iceland and linked to the Icelandic Cancer Registry. A total of 25, 546 relatives, including 2, 080 individuals with cancer were identified within these pedigrees. There was no statistically significant increase of glioma in relatives of glioma patients, nor was there any statistically significant increase in risk for other central nervous system tumors. There was no overall increase in incidence of all cancer combined, nor of specific common cancers (lung, prostate, breast, stomach, and colorectal) and uncommon cancers (melanoma and pancreas) in the relatives of glioma patients. Our results do not support the hypothesis of a familial aggregation of glioma indicative of a glioma susceptibility gene.

Original languageEnglish (US)
Pages (from-to)921-924
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Issue number9
StatePublished - Sep 2002

ASJC Scopus subject areas

  • Medicine(all)


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