Rheumatoid lung disease: Prognostic analysis of 54 biopsy-proven cases

Yutaro Nakamura, Takafumi Suda, Yusuke Kaida, Masato Kono, Hironao Hozumi, Dai Hashimoto, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Shiro Imokawa, Kazumasa Yasuda, Toshihiro Shirai, Hideki Suganuma, Satoru Morita, Hiroshi Hayakawa, Yasuo Takehara, Thomas V. Colby, Kingo Chida

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Objective: To investigate the prognostic significance of histopathological characteristics in patients with biopsy-proven rheumatoid lung disease (RLD). Materials and methods: Retrospective analysis was conducted on samples from 54 RLD patients who underwent surgical lung biopsies (SLBs) at Hamamatsu University Hospital and affiliated hospitals between 1980 and 2009. The overall survival rate, the spectrum of histopathological diagnosis and their associated prognostic significance were investigated. Results: The study group consisted of 30 men and 24 women with a median age of 60.3 years. Histopathological analysis revealed the following: usual interstitial pneumonia (UIP), 15 cases; nonspecific interstitial pneumonia/fibrosis, 16 cases; organizing pneumonia, 4 cases; unclassifiable, 2 cases; desquamative interstitial pneumonia, 1 case; and bronchiolar disease, 16 cases. In survival outcome, 10 yr survival rate was 76.6%. Patients with UIP had significantly worse prognosis than those with non-UIP (RLD cases except those with UIP) (p = 0.0452). Conclusion: RLD includes several histopathological groups. Patients with UIP have worse survival than those with other types of RLD. Histopathological diagnosis may have a major impact on prognostication in patients with RLD.

Original languageEnglish (US)
Pages (from-to)1164-1169
Number of pages6
JournalRespiratory Medicine
Issue number8
StatePublished - Aug 2012


  • Connective tissue disease
  • Histopathological diagnosis
  • Interstitial lung disease
  • Prognosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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