Reversible cerebral vasoconstriction syndrome

Holly Yancy, Joyce K. Lee-Iannotti, Todd J. Schwedt, David W. Dodick

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular disorder with a clinical picture that continues to be refined. It has presented to multiple subspecialties over the past several decades, bringing with it many questions regarding risk factors, diagnosis, and management. Answers have been forthcoming but many questions remain. RCVS presents with recurrent, secondary thunderclap headaches and predominantly affects young women. The mechanism of vasoconstriction is unclear, but there has been speculation regarding a hyperadrenergic state. Diagnosis requires physician awareness, vascular imaging, and knowledge of the differential. The hallmark of its diagnosis is reversibility. Management is empiric, usually with calcium-channel blockers, as there are no controlled treatment trials for RCVS. Randomized controlled trials are needed.

Original languageEnglish (US)
Pages (from-to)570-576
Number of pages7
Issue number3
StatePublished - Mar 2013


  • Call-Fleming syndrome
  • benign angiopathy of the central nervous system
  • reversible cerebral vasoconstriction syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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