Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

B. G. Weinshenker; G. Dekaban; G. P.A. Rice

doi:10.1212/wnl.40.8.1251

Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

B. G. Weinshenker, G. Dekaban, G. P.A. Rice

Neurology

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18 Scopus citations

Abstract

We were unable to identify an antibody to either HTLV-I or HIV-1 inpatients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

Original language	English (US)
Pages (from-to)	1251-1253
Number of pages	3
Journal	Neurology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1212/wnl.40.8.1251
State	Published - Aug 1990

ASJC Scopus subject areas

Clinical Neurology

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title = "Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay",

abstract = "We were unable to identify an antibody to either HTLV-I or HIV-1 inpatients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.",

author = "Weinshenker, {B. G.} and G. Dekaban and Rice, {G. P.A.}",

year = "1990",

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AB - We were unable to identify an antibody to either HTLV-I or HIV-1 inpatients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

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Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

Abstract

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