Responsiveness of a Histologic Scoring System Compared with Peak Eosinophil Count in Eosinophilic Esophagitis

Christopher Ma, Vipul Jairath, Brian G. Feagan, Leonardo Guizzetti, Guangyong Zou, Stefanie C. McFarlane, Lisa M. Shackelton, Margaret H. Collins, Ikuo Hirano, Willemijn E. De Rooij, David F. Schaeffer, Rish K. Pai, Albert J. Bredenoord, Evan S. Dellon

Research output: Contribution to journalArticlepeer-review


INTRODUCTION:The optimal instrument for assessing histologic disease activity in patients with eosinophilic esophagitis (EoE) is unclear. We assessed the responsiveness of the EoE Histologic Scoring System (EoE-HSS) when compared with that of the peak eosinophil count (PEC).METHODS:Histopathology slides were obtained from patients with EoE at baseline and after 8 weeks of treatment with swallowed topical budesonide or elimination diet. Two blinded gastrointestinal pathologists scored biopsies on the EoE-HSS, PEC, and 100-mm visual analog scale (VAS) of overall histologic severity. Change was defined as an improvement by ≥0.5 SD in baseline VAS. Responsiveness was quantified using the standardized effect size (SES) and the probability that the index distinguishes a patient with improvement from a patient without improvement, which is the area under the receiver operating characteristic curve (AUC). Longitudinal validity was assessed using Pearson correlations between changes in EoE-HSS and both PEC and VAS.RESULTS:The EoE-HSS grade (SES 2.18 [95% confidence interval, CI: 1.46-2.88]; AUC 0.73 [95% CI: 0.57-0.84]) and stage (SES 2.07 [95% CI: 1.37-2.77]; AUC 0.73 [95% CI: 0.58-0.84]) were highly responsive, similar to PEC (SES 1.44 [95% CI: 0.80-2.07]; AUC 0.73 [95% CI: 0.58-0.84]). The EoE-HSS grade and stage were more highly correlated with changes in VAS (grade 0.92 [95% CI: 0.86-0.95]; stage 0.89 [95% CI: 0.81-0.94]) than with changes in PEC (grade 0.74 [95% CI: 0.58-0.85]; stage 0.66 [95% CI: 0.47-0.80]).DISCUSSION:The EoE-HSS is highly responsive, performs similarly to PEC, and is better correlated with changes in overall histologic activity in patients with EoE.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalAmerican Journal of Gastroenterology
Issue number2
StatePublished - Feb 1 2022

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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