Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

Kamal S. Saini; Carlo Lanza; Marco Romano; Evandro de Azambuja; Javier Cortes; Begoña de las Heras; Javier de Castro; Monika Lamba Saini; Sibylle Loibl; Giuseppe Curigliano; Chris Twelves; Manuela Leone; Mrinal M. Patnaik

doi:10.1038/s41416-020-0948-x

Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

Kamal S. Saini
, Carlo Lanza
, Marco Romano
, Evandro de Azambuja
, Javier Cortes
, Begoña de las Heras
, Javier de Castro
, Monika Lamba Saini
, Sibylle Loibl
, Giuseppe Curigliano
, Chris Twelves
, Manuela Leone
, Mrinal M. Patnaik

Hematology

Research output: Contribution to journal › Comment/debate › peer-review

10 Scopus citations

Abstract

Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.

Original language	English (US)
Pages (from-to)	694-697
Number of pages	4
Journal	British journal of cancer
Volume	123
Issue number	5
DOIs	https://doi.org/10.1038/s41416-020-0948-x
State	Published - Sep 1 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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Saini, K. S., Lanza, C., Romano, M., de Azambuja, E., Cortes, J., de las Heras, B., de Castro, J., Lamba Saini, M., Loibl, S., Curigliano, G., Twelves, C., Leone, M., & Patnaik, M. M. (2020). Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy. British journal of cancer, 123(5), 694-697. https://doi.org/10.1038/s41416-020-0948-x

Saini, KS, Lanza, C, Romano, M, de Azambuja, E, Cortes, J, de las Heras, B, de Castro, J, Lamba Saini, M, Loibl, S, Curigliano, G, Twelves, C, Leone, M & Patnaik, MM 2020, 'Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy', British journal of cancer, vol. 123, no. 5, pp. 694-697. https://doi.org/10.1038/s41416-020-0948-x

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abstract = "Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.",

author = "Saini, \{Kamal S.\} and Carlo Lanza and Marco Romano and \{de Azambuja\}, Evandro and Javier Cortes and \{de las Heras\}, Bego{\~n}a and \{de Castro\}, Javier and \{Lamba Saini\}, Monika and Sibylle Loibl and Giuseppe Curigliano and Chris Twelves and Manuela Leone and Patnaik, \{Mrinal M.\}",

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doi = "10.1038/s41416-020-0948-x",

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AU - Saini, Kamal S.

AU - Lanza, Carlo

AU - Romano, Marco

AU - de Azambuja, Evandro

AU - Cortes, Javier

AU - de las Heras, Begoña

AU - de Castro, Javier

AU - Lamba Saini, Monika

AU - Loibl, Sibylle

AU - Curigliano, Giuseppe

AU - Twelves, Chris

AU - Leone, Manuela

AU - Patnaik, Mrinal M.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.

AB - Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.

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U2 - 10.1038/s41416-020-0948-x

DO - 10.1038/s41416-020-0948-x

M3 - Comment/debate

C2 - 32572174

AN - SCOPUS:85086774432

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JO - British journal of cancer

JF - British journal of cancer

IS - 5

ER -

Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

Abstract

ASJC Scopus subject areas

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