Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension

Lorenzo S. Malatino, Ignazio Bellanuova, Alessandro Cataliotti, Fortunata Cuzzola, Francesca Mallamaci, Giovanni Tripepi, Saverio Parlongo, Sebastiano Cutrupi, Roberto A. Mangiafico, Claudio Ferri, Ferruccio Galletti, Nicola Glorioso, Pasquale Strazzullo, Carmine Zoccali

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Methods: We investigated the influence of salt intake on urinary and plasma endothelin-1 (ET-1) in 55 patients who entered a two-week double-blind, randomised, crossover study comparing a 50 mMol/day salt intake and 150 mMol/day. Twenty-four-hour ET-1 excretion and plasma ET-1 were measured by RIA on pre-extracted samples. Results: In the whole cohort (n=55), changes in urinary ET-1 were related to salt excretion (r=0.28, P=0.04) and urinary volume (r=0.47, P=0.0001). In a multivariable model, changes in PRA, plasma aldosterone, blood pressure and heart rate did not add any predictive power to salt excretion with regard to urinary ET-1 variations. The relationship between urinary volume and urinary ET-1 was stronger than that of urinary sodium with ET-1 excretion because sodium was excluded from the multivariable model when urinary volume was introduced. Changes in urinary ET-1 were unrelated to mean blood pressure changes (P=0.66). Changes in plasma ET-1 were unaffected by changes in salt intake (P=0.58) but were strongly related to those in PRA (r=-0.45, P=0.01) and plasma aldosterone (r=-0.53, P=0.002). Conclusions: The renal excretion of ET-1 is influenced by changes in salt intake and appears largely independent of the blood pressure response to salt. Changes in urinary volume which accompany variations in salt excretion play an important role in this response. Since urinary ET-1 reflects its renal synthesis, our data support the notion that renal ET-1 plays a role in the regulation of sodium balance in patients with mild hypertension.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalJournal of Nephrology
Issue number3
StatePublished - May 2000


  • Endothelin
  • Hypertension
  • Natriuresis
  • Plasma aldosterone
  • Plasma renin activity

ASJC Scopus subject areas

  • Nephrology


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