Renal cortical perfusion-Preliminary experience with the Dynamic Spatial Reconstructor (DSR)

Tsutomu Iwasaki, Erik L. Ritman, Mary J. Fiksen-Olsen, Juan C. Romero, Franklyn G. Knox

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The three-dimensional image data generated by the Dynamic Spatial Reconstructor (DSR) enables measurement of the three-dimensional distribution of blood supply in organs. We have applied this imaging technique to evaluate renal cortical blood flow distribution and compare it with distribution of radiolabeled microspheres. The DSR, a high temporal resolution volumetric roentgenographic computed tomographic scanner, was used to scan the volume containing a kidney in 0.13-0.26 s and repeating this scan 8-4 times per s for six s during a renal arteriogram. Five anesthetized dogs were studied in the prone position with the left kidney exteriorized through a flank incision. An electromagnetic flowmeter was placed around the renal artery and a needle placed retrograde into the artery for injection of a 2 cc bolus of contrast agent. During the scan the contrast agent was injected over a four s period during which radioactively labelled microspheres were injected into the left atrium. The tomographic images of approximately 10 parallel, 5 mm thick sagittal slices corresponding to the slices of the kidney used for counting microspheres in the cortical layers were displayed and analyzed. The time point chosen for analysis was the one in which peak brightness (i.e., concentration of contrast agent) was detected in the cortex. The spatial distribution of peak brightness values was compared to the number of microspheres at the same sampling locations. The microsphere-based value of regional cortical blood flow fell below the regression line for the juxtamedullary cortex and above for the outer cortex. This result is consistent with the preferential distribution of microspheres to the outer cortex whereas the contrast agent distributed more uniformly throughout the cortex.

Original languageEnglish (US)
Pages (from-to)259-271
Number of pages13
JournalAnnals of Biomedical Engineering
Issue number3-4
StatePublished - May 1985


  • Perfusion
  • Renal cortex
  • Tomography
  • X-ray

ASJC Scopus subject areas

  • Biomedical Engineering


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