Renal cell-urinary crystal interactions

John C. Lieske, F. Gary Toback

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalCurrent opinion in nephrology and hypertension
Issue number4
StatePublished - 2000

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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