Relaxation of canine saphenous vein following brief transmural nerve stimulation

T. W. Rooke, T. J. Rimele, P. M. Vanhoutte

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The ability of electrical stimulation to cause relaxation in the canine saphenous vein was evaluated. Rings of vein were studied isometrically in organ chambers containing physiological salt solution. Prostaglandin F(2α) produced stable contractions during which brief periods of electrical stimulation caused further contraction. With cessation of the electrical stimulation, tension transiently decreased to a level below that observed prior to the stimulation (undershoot). This poststimulation undershoot was blocked by tetrodotoxin, phentolamine, ouabain, and potassium-free solution; it was not affected by atropine, cimetidine, indomethacin, ketanserin, methysergide, propranolol, pyrilamine, or removal of the endothelium. Undershoot did not occur following electrical stimulation during contractions evoked by norepinephrine. During superfusion with PGF(2α), a brief exposure to exogenous norepinephrine caused a transient contraction followed by a subsequent undershoot. These results suggest that 1) the interaction of norepinephrine with postjunctional α-adrenoceptors on vascular smooth muscle leads to an increase in the activity of Na+K+-ATPase, and 2) increased activity of Na+-K+-ATPase is responsible for the poststimulation undershoot.

Original languageEnglish (US)
Pages (from-to)H1073-H1076
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6
StatePublished - 1983

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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