Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Jamie L. Archambault; Teri L. Hernandez; Eva S. Nozik; Claire Palmer; Mairead Dillon; Ravinder J. Singh; Csaba Galambos; Cassidy A. Delaney

doi:10.1016/j.jpeds.2024.114290

Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Jamie L. Archambault, Teri L. Hernandez, Eva S. Nozik, Claire Palmer, Mairead Dillon, Ravinder J. Singh, Csaba Galambos, Cassidy A. Delaney

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

Original language	English (US)
Article number	114290
Journal	Journal of Pediatrics
Volume	276
DOIs	https://doi.org/10.1016/j.jpeds.2024.114290
State	Published - Jan 2025

Keywords

neonate
pulmonary hypertension
serotonin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2024.114290

Cite this

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title = "Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn",

abstract = "Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.",

keywords = "neonate, pulmonary hypertension, serotonin",

author = "Archambault, {Jamie L.} and Hernandez, {Teri L.} and Nozik, {Eva S.} and Claire Palmer and Mairead Dillon and Singh, {Ravinder J.} and Csaba Galambos and Delaney, {Cassidy A.}",

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doi = "10.1016/j.jpeds.2024.114290",

language = "English (US)",

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AU - Archambault, Jamie L.

AU - Hernandez, Teri L.

AU - Nozik, Eva S.

AU - Palmer, Claire

AU - Dillon, Mairead

AU - Singh, Ravinder J.

AU - Galambos, Csaba

AU - Delaney, Cassidy A.

PY - 2025/1

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N2 - Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

AB - Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

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KW - pulmonary hypertension

KW - serotonin

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ER -

Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Abstract

Keywords

ASJC Scopus subject areas

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