Regulation of T-cell activation by the cytoskeleton

Daniel D. Billadeau, Jeffrey C. Nolz, Timothy S. Gomez

Research output: Contribution to journalReview articlepeer-review

255 Scopus citations


To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.

Original languageEnglish (US)
Pages (from-to)131-143
Number of pages13
JournalNature Reviews Immunology
Issue number2
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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