@article{fa065fc9038440489cc6a2d8482f023f,
title = "Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies",
abstract = "Magnetic resonance spectroscopy (MRS) characteristics of dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and cognitively normal controls were compared. DLB (n= 34), AD (n= 35), and cognitively normal controls (n= 148) participated in a MRS study from frontal, posterior cingulate, and occipital voxels. We investigated DLB patients with preserved hippocampal volumes to determine the MRS changes in DLB with low probability of overlapping AD pathology. DLB patients were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) in the occipital voxel. AD patients were characterized by lower NAA/Cr in the frontal and posterior cingulate voxels. Normal NAA/Cr levels in the frontal voxel differentiated DLB patients with preserved hippocampal volumes from AD patients. DLB and AD patients had elevated choline/creatine, and myo-Inositol/creatine in the posterior cingulate. MRS abnormalities associated with loss of neuronal integrity localized to the occipital lobes in DLB, and the posterior cingulate gyri and frontal lobes in AD. This pattern of MRS abnormalities may have a role in differential diagnosis of DLB and in distinguishing DLB patients with overlapping AD pathology.",
keywords = "Alzheimer's disease, Dementia with Lewy bodies, Magnetic resonance spectroscopy",
author = "Jonathan Graff-Radford and Boeve, {Bradley F.} and Murray, {Melissa E.} and Ferman, {Tanis J.} and Nirubol Tosakulwong and Lesnick, {Timothy G.} and Mandie Maroney-Smith and Senjem, {Matthew L.} and Jeffrey Gunter and Smith, {Glenn E.} and Knopman, {David S.} and Jack, {Clifford R.} and Dickson, {Dennis W.} and Petersen, {Ronald C.} and Kejal Kantarci",
note = "Funding Information: Dr Boeve has served as an investigator for a clinical trial sponsored by Cephalon, Inc. He has received honoraria from the American Academy of Neurology. He receives research support from the National Institute on Aging ( P50-AG16574 [Co-I], U01 AG06786 [Co-I], R01-AG15866 [Co-I], and U24-AG26395 [Co-I]), and the Alzheimer's Association (IIRG-05–14,560 [PI]). Dr Ferman is funded by the NIH (Mayo Clinic Alzheimer's Disease Research Center/Project 1-P50-AG16574/P1 [Co-I]). Dr Smith is funded by the NIH (P50-AG16574). Dr Knopman serves as Deputy Editor for Neurology; served on a Data Safety Monitoring Board for Lilly Pharmaceuticals; served as a consultant to TauRx, was an investigator in clinical trials sponsored by Baxter, Elan Pharmaceuticals, and Forest Pharmaceuticals for the past 2 years; and receives research support from the NIH. Dr Jack serves as a consultant for Janssen, Bristol-Meyer-Squibb, General Electric, Siemens, and Johnson and Johnson and is involved in clinical trials sponsored by Allon and Baxter, Inc. He receives research funding from the National Institutes of Health ( R01-AG011378 , RO1-AG037551 , U01-HL096917 , U01-AG032438 , U01-AG024904 ), and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation Family. Dr Petersen serves on scientific advisory boards for Elan Pharmaceuticals, Wyeth Pharmaceuticals, and GE Healthcare and receives research support from the NIH (P50-AG16574 [PI] and U01-AG06786 [PI], R01-AG11378 [Co-I], and U01–24904 [Co-I]). Dr Dickson is funded by the NIH (P50-AG16574/Neuropathology Core [PI], P01AG017216 [PI], P50-NS072187 [PI], and R01-AG040042 [Co-I]). Dr Kantarci serves on the data safety monitoring board for Pfizer Inc and Takeda Global Research & Development Center, Inc; and she is funded by the NIH (R01AG040042 [PI], R21 NS066147 [PI], P50 AG44170 /Project 2 [PI], P50 AG16574/Project 1 [PI], and R01 AG11378 [Co-I]). Funding Information: NIH ( K23 AG030935 , R01 AG040042, R01 AG11378, P50 AG44170, P50 AG16574, U01 AG06786, C06 RR018898 ), Mangurian Foundation , and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program .",
year = "2014",
month = jun,
doi = "10.1016/j.neurobiolaging.2014.01.001",
language = "English (US)",
volume = "35",
pages = "1483--1490",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "6",
}