TY - JOUR
T1 - Regional Metal Concentrations in Parkinson's Disease, Other Chronic Neurological Diseases, and Control Brains
AU - Uitti, Ryan J.
AU - Rajput, A. H.
AU - Rozdilsky, B.
AU - Bickis, M.
AU - Wollin, T.
AU - Yuen, W. K.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/8
Y1 - 1989/8
N2 - Metal deficiency or toxicity states have been recognized as a cause of several neurological disorders and are suspected in others. We analyzed four brain regions (frontal cortex, caudate nucleus, substantia nigra, and cerebellum) in 36 human brains for concentrations of 24 metals (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn). Regional metal concentrations, measured using atomic absorption and atomic emission spectroscopy, were compared between 9 Parkinson's disease (PD) brains, 15 brains from patients with other chronic neurological diseases, and 12 control brains. No significant metal concentration differences were noted between brains from PD and other chronic neurologic disease. However, parkinsonian brains (PD and parkinsonism secondary to neurofibrillary tangle disease) showed lower concentrations of magnesium in the caudate nucleus and copper in the substantia nigra than control brains. These findings may represent an etiologically important clue to parkinsonism.
AB - Metal deficiency or toxicity states have been recognized as a cause of several neurological disorders and are suspected in others. We analyzed four brain regions (frontal cortex, caudate nucleus, substantia nigra, and cerebellum) in 36 human brains for concentrations of 24 metals (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn). Regional metal concentrations, measured using atomic absorption and atomic emission spectroscopy, were compared between 9 Parkinson's disease (PD) brains, 15 brains from patients with other chronic neurological diseases, and 12 control brains. No significant metal concentration differences were noted between brains from PD and other chronic neurologic disease. However, parkinsonian brains (PD and parkinsonism secondary to neurofibrillary tangle disease) showed lower concentrations of magnesium in the caudate nucleus and copper in the substantia nigra than control brains. These findings may represent an etiologically important clue to parkinsonism.
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U2 - 10.1017/S0317167100029140
DO - 10.1017/S0317167100029140
M3 - Article
C2 - 2766123
AN - SCOPUS:0024339772
SN - 0317-1671
VL - 16
SP - 310
EP - 314
JO - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
JF - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
IS - 3
ER -