Regenerative chimerism bioengineered through stem cell reprogramming

Timothy J. Nelson, Almudena Martinez-Fernandez, Satsuki Yamada, Andre Terzic

Research output: Chapter in Book/Report/Conference proceedingChapter


Regenerative medicine aims to restore damaged tissues in order to reverse disease progression and provide a sustainable solution that cures the root cause of the disease process. Although natural mechanisms of repair are ubiquitous, disruption of the homeostatic balance affects the equilibrium between health and disease due to insufficient tissue renewal in chronic degenerative conditions. Augmentation of the diseased tissue repair capacity through chimerism offers a strategy that spans all fields of medicine and surgery from natural chimerism for tissue rejuvenation, to surgical chimerism for organ replacement, to bioengineered chimerism for targeted regeneration. Technological breakthroughs in nuclear reprogramming now provide a platform to advance a broad range of solutions for regenerative medicine built on the foundation of pluripotent autologous stem cells. By optimizing the safety and effectiveness for stem cell production and ensuring tissue- specific differentiation of progenitors, induced pluripotent stem cells (iPS) offer an unprecedented opportunity to accelerate personalized applications with cell-based products to bioengineer health from disease.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine - from Protocol to Patient
Subtitle of host publication3. Tissue Engineering, Biomaterials and Nanotechnology: Third Edition
PublisherSpringer International Publishing
Number of pages24
ISBN (Electronic)9783319282749
ISBN (Print)9783319282725
StatePublished - Apr 12 2016


  • Cardiac repair
  • Chimerism
  • Regeneration
  • Rejuvenation

ASJC Scopus subject areas

  • General Medicine


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