Refractory Celiac Disease

Georgia Malamut; Joseph A. Murray; Christophe Cellier

doi:10.1016/j.giec.2012.07.007

Refractory Celiac Disease

Georgia Malamut, Joseph A. Murray, Christophe Cellier

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

A small subset of patients with celiac disease become refractory to a gluten-free diet, with persistent or recurrent symptoms of malabsorption and intestinal villous atrophy. This condition, defined as refractory celiac disease (RCD), is diagnosed after other small bowel diseases with villous atrophy are excluded. RCD is subdivided into 2 subgroups: type I RCD and type II RCD (RCDII). This latter condition is considered a low-grade intraepithelial lymphoma and has a poor prognosis. This article reviews the clinical and pathologic features of RCD and recent pathogenic findings in RCDII, offering a model to study how inflammation can drive T-cell lymphomagenesis.

Original language	English (US)
Pages (from-to)	759-772
Number of pages	14
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.giec.2012.07.007
State	Published - Oct 1 2012

Keywords

Aberrant intraepithelial lymphocytes
Immunosuppressive treatments
Refractory celiac disease

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.giec.2012.07.007

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title = "Refractory Celiac Disease",

abstract = "A small subset of patients with celiac disease become refractory to a gluten-free diet, with persistent or recurrent symptoms of malabsorption and intestinal villous atrophy. This condition, defined as refractory celiac disease (RCD), is diagnosed after other small bowel diseases with villous atrophy are excluded. RCD is subdivided into 2 subgroups: type I RCD and type II RCD (RCDII). This latter condition is considered a low-grade intraepithelial lymphoma and has a poor prognosis. This article reviews the clinical and pathologic features of RCD and recent pathogenic findings in RCDII, offering a model to study how inflammation can drive T-cell lymphomagenesis.",

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AU - Malamut, Georgia

AU - Murray, Joseph A.

AU - Cellier, Christophe

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N2 - A small subset of patients with celiac disease become refractory to a gluten-free diet, with persistent or recurrent symptoms of malabsorption and intestinal villous atrophy. This condition, defined as refractory celiac disease (RCD), is diagnosed after other small bowel diseases with villous atrophy are excluded. RCD is subdivided into 2 subgroups: type I RCD and type II RCD (RCDII). This latter condition is considered a low-grade intraepithelial lymphoma and has a poor prognosis. This article reviews the clinical and pathologic features of RCD and recent pathogenic findings in RCDII, offering a model to study how inflammation can drive T-cell lymphomagenesis.

AB - A small subset of patients with celiac disease become refractory to a gluten-free diet, with persistent or recurrent symptoms of malabsorption and intestinal villous atrophy. This condition, defined as refractory celiac disease (RCD), is diagnosed after other small bowel diseases with villous atrophy are excluded. RCD is subdivided into 2 subgroups: type I RCD and type II RCD (RCDII). This latter condition is considered a low-grade intraepithelial lymphoma and has a poor prognosis. This article reviews the clinical and pathologic features of RCD and recent pathogenic findings in RCDII, offering a model to study how inflammation can drive T-cell lymphomagenesis.

KW - Aberrant intraepithelial lymphocytes

KW - Immunosuppressive treatments

KW - Refractory celiac disease

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Refractory Celiac Disease

Abstract

Keywords

ASJC Scopus subject areas

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