Reelin expression is upregulated following ocular tissue injury

Jose S. Pulido, Ikuko Sugaya, Jordan Comstock, Kiminobu Sugaya

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: Reelin is important in the guidance of neuronal stem cells in the central nervous system during normal development. We wished to determine whether reelin is expressed in the retina and cornea after injury. Methods: Mice underwent laceration of their retina as well as corneal epithelial debridement. The mice were sacrificed at 3 days, and eyes were fixed and stained for reelin expression and reelin messenger ribonucleic acid (mRNA). Results: In normal eyes, reelin was expressed only at very low levels in the ganglion cell layer of the retina and the endothelial cell layer of the cornea. In injured eyes, there was marked expression in reelin immunoreactivity in the retina and cornea. Reelin gene expression was seen in the retina and cornea. Conclusions: Reelin is expressed during normal retinogenesis. This study shows that reelin is also upregulated following injury to the retina and cornea. The expression of reelin following injury suggests that reelin may play an important role in regulating stem cell trafficking in neuronal and nonneuronal tissues following injury similar to its role in normal organogenesis.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number6
StatePublished - Jun 2007


  • Cornea
  • Migration
  • Reelin
  • Regeneration
  • Retina
  • Stem cell

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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