Recommendations from the national multiple sclerosis society clinical outcomes assessment task force

Richard Rudick, Jack Antel, Christian Confavreux, Gary Cutter, George Ellison, Jill Fischer, Fred Lublin, Aaron Miller, John Petkau, Stephen Rao, Stephen Reingold, Karl Syndulko, Alan Thompson, Joy Wallenberg, Brian Weinshenker, Ernest Willoughby

Research output: Contribution to journalArticlepeer-review

310 Scopus citations


This article provides recommendations from the National Multiple Sclerosis Society's Clinical Outcomes Assessment Task Force. The Task Force was appointed in 1994 and charged with recommendending improved approaches for clinical outcomes assessment in future controlled clinical trials. The recommendations herein follow extensive deliberation and data analysis during 2.5 years. General principles and desirable measurement attributes were used to assess alternative measurement techniques and clinical scales. On the basis of the analysis of existing multiple sclerosis (MS) data sets, a new measurement approach is proposed. The approach is based on quantitative functional composites that consist of simple quantitative measures from the major clinical dimensions of MS combined into a single score. Quantitative functional composites are likely to provide improved precision and sensitivity in future MS clinical trials. Studies necessary to further refine quantitative functional composites as useful MS clinical trial outcomes are delineated.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalAnnals of neurology
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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