Recommendations for hormone therapy in hysterectomized women: Importance of new data in clinical management

Stephanie S. Faubion, Ekta Kapoor, Carol L. Kuhle, Richa Sood, Jacqueline M. Thielen, Virginia M. Miller

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Women with a prior hysterectomy with and without oophorectomy represent special cohorts among those who require menopausal hormone therapy (HT), as a progestogen is not required for endometrial protection. This is relevant in light of recent research demonstrating superiority of estrogen therapy alone compared with estrogen plus a progestogen with respect to breast cancer risk and perhaps even cardiovascular protection. No longer is it appropriate to lump all HT regimens together when advising patients. Unfortunately, there is a general reluctance in the healthcare community to prescribe HT even a decade after publication of the results of the Women's Health Initiative trial. However, with subsequent research showing a favorable benefit/risk balance of short-term estrogen therapy in symptomatic, recently menopausal women, especially those who have undergone hysterectomy with oophorectomy, the need for educating patients and providers on the matter cannot be overemphasized.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalExpert Review of Endocrinology and Metabolism
Issue number1
StatePublished - Jan 1 2015


  • Estrogen therapy
  • hormone replacement
  • hormone therapy
  • hysterectomy
  • menopause
  • oophorectomy
  • premature menopause

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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