Real-World Clinical Outcomes of Bamlanivimab and Casirivimab-Imdevimab among High-Risk Patients with Mild to Moderate Coronavirus Disease 2019

Ravindra Ganesh, Lindsey M. Philpot, Dennis M. Bierle, Ryan J. Anderson, Lori L. Arndt, Richard F. Arndt, Tracy L. Culbertson, Molly J. Destro Borgen, Sara N. Hanson, Brian D. Kennedy, Brian B. Kottke, Jennifer J. Larsen, Priya Ramar, Jordan K. Rosedahl, Maria Teresa Seville, Leigh L. Speicher, Sidna M. Tulledge-Scheitel, Caroline G. Wilker, Raymund R. Razonable

Research output: Contribution to journalArticlepeer-review


Background: Bamlanivimab and casirivimab-imdevimab are authorized for treatment of mild to moderate coronavirus disease 2019 (COVID-19) in high-risk patients. We compared the outcomes of patients who received these therapies to identify factors associated with hospitalization and other clinical outcomes. Methods: Adult patients who received monoclonal antibody from 19 November 2020 to 11 February 2021 were selected and divided into those who received bamlanivimab (n=2747) and casirivimab-imdevimab (n=849). The 28-day all-cause and COVID-19-related hospitalizations were compared between the groups. Results: The population included 3596 patients; the median age was 62 years, and 50% were female. All had ≥1 medical comorbidity; 55% had multiple comorbidities. All-cause and COVID-19-related hospitalization rates at 28 days were 3.98% and 2.56%, respectively. After adjusting for medical comorbidities, there was no significant difference in all-cause and COVID-19-related hospitalization rates between bamlanivimab and casirivimab-imdevimab (adjusted hazard ratios [95% confidence interval], 1.4 [.9-2.2] and 1.6 [.8-2.7], respectively). Chronic kidney, respiratory and cardiovascular diseases, and immunocompromised status were associated with higher likelihood of hospitalization. Conclusions: This observational study on the use of bamlanivimab and casirivimab-imdevimab in high-risk patients showed similarly low rates of hospitalization. The number and type of medical comorbidities are associated with hospitalizations after monoclonal antibody treatment.

Original languageEnglish (US)
Pages (from-to)1278-1286
Number of pages9
JournalJournal of Infectious Diseases
Issue number8
StatePublished - Oct 15 2021


  • COVID-19
  • bamlanivimab
  • casirivimab
  • hospitalization
  • outcomes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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