Real-time digital K-edge subtraction fluoroscopy

Theodore L. Houk, Robert A. Kruger, Charles A. Mistretta, Stephen J. Riederer, Chorng Gang Shaw, Jerome C. Lancaster, David C. Flemming

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


We report in vitro and in vivo trials of K-edge fluoroscopy, by which iodine contrast concentration is displayed live, with tissue and bone images suppressed, free of patient-motion artifacts. Iodine and cerium, 125 and 225 mg/cm2 respectively, filter alternate TV fields of cine-pulsed 50 KVP x-rays. Weighted subtraction of successive TV fields isolates the iodine image and simultaneously minimizes artifacts. Digital techniques are used in real time. At our present x-ray tube limit, 500 mA instantaneous current, the patient exposure is 180 mR/sec and quantum mottle limits the image quality. Integrating four successive difference images provides a compromise between mottle and smoothly moving displays. Cardiovascular images of a 17-kg dog, using 1 ml/kg Renografin-60 injected into a foreleg vein, show that a 15-cm chest thickness is our present practical maximum. This method may be useful in diagnosing cardiovascular anomalies in infants without catheterization or suspension of breathing.

Original languageEnglish (US)
Pages (from-to)270-278
Number of pages9
JournalInvestigative radiology
Issue number4
StatePublished - 1979

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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