Abstract
Ras-GTP-Raf complexes play an important role in the RTKs-mediated Ras pathway. The molecular mechanism of signal transduction in the Ras-GTP-Raf complexes is that the complexes switch signal transduction, trigger signal amplification cascade and may be involved in neoplasia. In addition, Ras-GTP-Raf complexes are essential in the PKC-mediated activation of Raf.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374 |
| Number of pages | 1 |
| Journal | Progress in Biochemistry and Biophysics |
| Volume | 27 |
| Issue number | 4 |
| State | Published - 2000 |
Keywords
- Ras-GTP-Raf complexes
- Signal transduction
- Tumour
ASJC Scopus subject areas
- Biophysics
- Biochemistry