Radiocontrast increases plasma and urinary endothelin

Kenneth B. Margulies, Fredric L. Hildebrand, Denise M. Heublein, John C. Burnett

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84 Scopus citations


Recent studies indicate that endothelin (ET), a potent endogenous systemic and renal vasoconstrictor peptide, may mediate decreases in GFR in models of acute renal dysfunction. Moreover, in an animal model of radiocontrast-induced nephropathy (RCIN), it was recently demonstrated that early renal hemodynamic responses to radiocontrast are attenuated by intra-arterial atrial natriuretic factor (ANF), which prevents subsequent RCIN. The studies presented here were therefore designed to determine whether i.v. infusion of radiocontrast produces increases in endogenous plasma and urinary ET and whether these responses are modulated by intraarterial ANF in an animal model of RCIN. In these studies, dogs with pacing-induced heart failure received i.v. radiocontrast in the presence and absence of an intra-aortic infusion of ANF. Significant increases in both plasma and urinary ET were observed during and after radiocontrast. Although coadministration of ANF did not prevent increases in plasma and urinary ET, ANF preserved renal function acutely in this model of RCIN by increasing GFR above baseline levels.

Original languageEnglish (US)
Pages (from-to)1041-1045
Number of pages5
JournalJournal of the American Society of Nephrology
Issue number5
StatePublished - Nov 1991


  • Acute renal failure
  • Atrial natriuretic factor
  • Endothelin
  • Radiocontrast
  • Renal hemodynamics

ASJC Scopus subject areas

  • General Medicine


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