Quality-of-Life Assessment in Patients Treated with Vagus Nerve Stimulation

Erhan Ergene, Pamela K. Behr, Jerry J. Shih

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Vagus nerve stimulation (VNS) is a novel therapy used in patients with medically intractable epilepsy. We administered a Quality of Life in Epilepsy - 10 (QOLIE-10) questionnaire consisting of questions designed to assess the patients' rating of their memory, level of physical and mental well-being, energy, depression, worries about seizures and work, social limitations, and overall quality of life on VNS treatment. The questionnaire was administered before and at 1-3 weeks, 5-7 weeks, 3 months, 6 months, and 9-12 months after the initiation of VNS in 17 patients. QOLIE-10 scores were significantly better after the initiation of the therapy as compared with baseline (P < 0.01). There was no correlation between the improvement in QOLIE-10 scores and the reduction in seizure frequency, decreased severity of seizures, or increased level of energy/alertness. We conclude that VNS therapy is associated with a significant improvement in subjective quality of life.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalEpilepsy and Behavior
Issue number3
StatePublished - Jun 2001


  • Vagus nerve stimulation; quality of life; refractory epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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