Quality assessment of the guidelines on cystic neoplasms of the pancreas

Massimo Falconi, Stefano Crippa, Suresh Chari, Kevin Conlon, Sun Whe Kim, Philippe Levy, Masao Tanaka, Jens Werner, Christopher L. Wolfgang, Raffaele Pezzilli, Carlos Fernandez Del Castillo

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Background Though cystic pancreatic neoplasms (CPNs) are being increasingly detected, their evaluation and management are still debated and have lead to publication of multiple guidelines for diagnostic work-up, indications for resection, and non-operative management with follow-up strategies of CPNs. Aims To analyze available guidelines in order to evaluate their overall quality and clinical applicability, indications for surgical resection and its extent, modalities and timing of follow-up when non-operative management is indicated. Methods After a systematic search of the English literature, we selected eight guidelines for assessment according to the Appraisal of Guidelines, Research and Evaluation in Europe (AGREE) II instrument. Results One guideline received the lower AGREE score regarding the "scope and purpose", "rigor of development" and "clarity and presentation" domains, whereas one received the best score for "stakeholder involvement" domain. No differences were found among different guidelines regarding the "applicability". The overall quality assessment score showed that only two guidelines were significantly lower than the others. According to the practical utilization recommendation score, four guidelines were considered as having full applicability in clinical practice. Conclusion Existing guidelines provide adequate guidance, at least with the present knowledge, for the management of cystic pancreatic lesions; however, not any one was satisfactory to all aspects related to the management of CPN. An update of the existing guidelines should be considered if and when more evidence-based data are available.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
Issue number5
StatePublished - Sep 2015


  • ADAPTE method
  • AGREE instrument
  • Diagnosis
  • Follow-up
  • Mucinous cystic neoplasm
  • Pancreatic cystic lesions

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology


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