Publication bias: A brief review for clinicians

Victor M. Montori, Marek Smieja, Gordon H. Guyatt

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


Systematic reviews and meta-analyses provide the highest level of evidence to guide clinical decisions and inform practice guidelines. Publication bias results from the selective publication of studies based on the direction and magnitude of their resultsstudies without statistical significance (negative studies) are less likely to be published. Bias results from pooling the results from published studies alone leading to overestimation of the effectiveness of the intervention. In this review we define publication bias, how it affects the results of systematic reviews, how it can be detected and minimized, and how it can be prevented.

Original languageEnglish (US)
Pages (from-to)1284-1288
Number of pages5
JournalMayo Clinic proceedings
Issue number12
StatePublished - 2000

ASJC Scopus subject areas

  • Medicine(all)


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