Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Wei Su; Nicole M. Chapman; Jun Wei; Hu Zeng; Yogesh Dhungana; Hao Shi; Jordy Saravia; Peipei Zhou; Lingyun Long; Sherri Rankin; Anil KC; Peter Vogel; Hongbo Chi

doi:10.1016/j.cmet.2020.10.022

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells

Wei Su
, Nicole M. Chapman
, Jun Wei
, Hu Zeng
, Yogesh Dhungana
, Hao Shi
, Jordy Saravia
, Peipei Zhou
, Lingyun Long
, Sherri Rankin
, Anil KC
, Peter Vogel
, Hongbo Chi

Rheumatology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector T_reg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in T_reg cell-mediated immune suppression.

Original language	English (US)
Pages (from-to)	996-1011.e7
Journal	Cell Metabolism
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2020.10.022
State	Published - Dec 1 2020

Keywords

Fntb
Pggt1b
Treg cells
immunometabolism
mTOR
protein prenylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2020.10.022

Cite this

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title = "Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells",

abstract = "Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.",

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AU - Su, Wei

AU - Chapman, Nicole M.

AU - Wei, Jun

AU - Zeng, Hu

AU - Dhungana, Yogesh

AU - Shi, Hao

AU - Saravia, Jordy

AU - Zhou, Peipei

AU - Long, Lingyun

AU - Rankin, Sherri

AU - KC, Anil

AU - Vogel, Peter

AU - Chi, Hongbo

PY - 2020/12/1

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AB - Su et al. show that mevalonate metabolism-driven protein geranylgeranylation and farnesylation orchestrate the respective differentiation and maintenance of effector Treg cells, by serving as rheostats for immunological receptor, mTORC1, and Rac signaling. These data establish a crucial role for metabolism-dependent posttranslational lipid modifications in Treg cell-mediated immune suppression.

KW - Fntb

KW - Pggt1b

KW - Treg cells

KW - immunometabolism

KW - mTOR

KW - protein prenylation

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