Prolonged refractory status epilepticus related to thrombotic thrombocytopenic purpura

Alexander Y. Zubkov, Alejandro A. Rabinstein, Edward M. Manno, Eelco F.M. Wijdicks

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Thrombotic thrombocytopenic purpura (TTP) is an extremely rare cause of status epilepticus. Review of literature demonstrated only four cases of brief status epilepticus (SE) associated with TTP. Case: We describe a young woman with yet incomplete neurological recovery after prolonged refractory status epilepticus. Management required pentobarbital-induced coma for 60 days. Five months after onset, she was conversant and oriented with continued neuromuscular deficits. Conclusions: This is an unusual presentation of severe refractory SE associated with TTP. With aggressive life support and prolonged pentobarbital infusion, however, survival and the chance of meaningful recovery appear to be possible.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalNeurocritical care
Issue number3
StatePublished - Dec 2008


  • Status epilepticus
  • TTP

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Prolonged refractory status epilepticus related to thrombotic thrombocytopenic purpura'. Together they form a unique fingerprint.

Cite this