Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration

Lei Zhang, Zhiqing Zhang, Yunhui Liu, Yixue Xue, Ian Parney

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalMedical Hypotheses
Issue number2
StatePublished - 2015

ASJC Scopus subject areas

  • General Medicine


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