Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartelink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Köbrunner, Anthony HowellClaudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Peter I. Pressman, Lawrence J. Solin, Michael Untch

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts.

Original languageEnglish (US)
Pages (from-to)4-16
Number of pages13
JournalBreast Journal
Issue number1
StatePublished - Jan 2009


  • BRCA
  • Breast cancer
  • Genetics
  • Risk

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology


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