@article{54a6fd156df247fb9597890f4da8f127,
title = "Probing circuit of Papez with stimulation of anterior nucleus of the thalamus and hippocampal evoked potentials",
abstract = "Purpose: Despite documented clinical effectiveness, deep brain stimulation (DBS) therapy for drug-resistant epilepsy rarely yields long-term seizure free outcomes. Methods: This pilot study in five patients investigated circuit of Papez evoked potentials (EPs) using hippocampal sensing during anterior nucleus of the thalamus (ANT) electrical stimulation. We hypothesize that hippocampal EP is a potential biomarker that could be useful for ANT electrode targeting and improving seizure reduction. We obtained bilateral circuit of Papez EPs in five patients with bilateral temporal lobe epilepsy (TLE). The circuit of Papez EPs were measured and assessed by signal amplitude. Volumetric analysis of relevant mesial temporal structures and ANT stimulation analysis was performed on immediate post-implantation images. Results: The patient with the most favorable seizure outcome, which meant long-term seizure reduction greater than 50 % compared to baseline, had strong bilateral EPs and normal hippocampal structure. Conversely, those without clinical benefit with ANT DBS had absent or weak bilateral EPs as well as MRI findings consistent with mesial temporal sclerosis (MTS). Conclusion: The data support the hypothesis that hippocampal EPs with ANT stimulation may be used to as a surrogate marker to probe circuit of Papez and predict ANT DBS efficacy.",
keywords = "Anterior nucleus of thalamus, Deep brain stimulation, Epilepsy, Evoked potentials, Mesial temporal sclerosis",
author = "Wang, {Yu Chi} and Vaclav Kremen and Brinkmann, {Benjamin H.} and Middlebrooks, {Erik H.} and Lundstrom, {Brian N.} and Grewal, {Sanjeet S.} and Hari Guragain and Wu, {Min Hsien} and {Van Gompel}, {Jamie J.} and Klassen, {Bryan T.} and Matt Stead and Worrell, {Gregory A.}",
note = "Funding Information: This study was supported by Medtronic and Cadence Neuroscience Inc. Drs. Brinkmann, Stead, Worrell, and Van Gompel have rights to receive future royalties from the licensing of technology related to brain stimulation research developed by Cadence Neuroscience Inc, which is co-owned by Mayo Clinic. The development of Cadence Neuroscience Inc. has been assisted by Drs. Brinkmann, Stead, Worrell, Van Gompel, and Lundstrom. The authors confirm that they have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.The authors thank Karla K. Crockett, and Erin M. Jagodzinski for their support of research coordination and administrative affairs. This research was supported by NIH grants UH2NS095495 and R01NS092882, and institutional resources for research by Czech Technical University in Prague, Czech Republic. Funding Information: This study was supported by Medtronic and Cadence Neuroscience Inc . Drs. Brinkmann, Stead, Worrell, and Van Gompel have rights to receive future royalties from the licensing of technology related to brain stimulation research developed by Cadence Neuroscience Inc, which is co-owned by Mayo Clinic. The development of Cadence Neuroscience Inc. has been assisted by Drs. Brinkmann, Stead, Worrell, Van Gompel, and Lundstrom. The authors confirm that they have read the Journal{\textquoteright}s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Publisher Copyright: {\textcopyright} 2019",
year = "2020",
month = jan,
doi = "10.1016/j.eplepsyres.2019.106248",
language = "English (US)",
volume = "159",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
}