Prevention of collagen induced arthritis in mice by deletion of t cell receptor vβ8 bearing t cells with monoclonal antibodies

K. G. Moder; H. S. Luthra; M. Griffiths; C. S. David

doi:10.1093/rheumatology/32.1.26

Prevention of collagen induced arthritis in mice by deletion of t cell receptor vβ8 bearing t cells with monoclonal antibodies

K. G. Moder, H. S. Luthra, M. Griffiths, C. S. David

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes Vβ8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete Vβ6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 4.66B5 treated animals was not significantly different from controls. Thus, the Vβ8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.

Original language	English (US)
Pages (from-to)	26-30
Number of pages	5
Journal	Rheumatology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1093/rheumatology/32.1.26
State	Published - Jan 1993

Keywords

Animal models of human disease
Autoimmunity
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

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10.1093/rheumatology/32.1.26

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title = "Prevention of collagen induced arthritis in mice by deletion of t cell receptor vβ8 bearing t cells with monoclonal antibodies",

abstract = "Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes Vβ8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete Vβ6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 4.66B5 treated animals was not significantly different from controls. Thus, the Vβ8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.",

keywords = "Animal models of human disease, Autoimmunity, Rheumatoid arthritis",

author = "Moder, {K. G.} and Luthra, {H. S.} and M. Griffiths and David, {C. S.}",

note = "Funding Information: These studies were supported by grants from National Institutes of Health (AR-30752), Minnesota Arthritis Foundation and the Mayo Foundation.",

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T1 - Prevention of collagen induced arthritis in mice by deletion of t cell receptor vβ8 bearing t cells with monoclonal antibodies

AU - Moder, K. G.

AU - Luthra, H. S.

AU - Griffiths, M.

AU - David, C. S.

N1 - Funding Information: These studies were supported by grants from National Institutes of Health (AR-30752), Minnesota Arthritis Foundation and the Mayo Foundation.

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N2 - Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes Vβ8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete Vβ6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 4.66B5 treated animals was not significantly different from controls. Thus, the Vβ8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.

AB - Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes Vβ8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete Vβ6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 4.66B5 treated animals was not significantly different from controls. Thus, the Vβ8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.

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Prevention of collagen induced arthritis in mice by deletion of t cell receptor vβ8 bearing t cells with monoclonal antibodies

Abstract

Keywords

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