Pregnancy: a clue to normal regulation of B lymphopoiesis

Paul W. Kincade, Kay L. Medina, Glennda Smithson, Denise C. Scott

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalImmunology Today
Issue number11
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Immunology


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