Predisposed to doze: Promethazine, CYP2D6 poor metabolizer

Erica D. Wittwer, Juraj Sprung, Wayne T. Nicholson

Research output: Chapter in Book/Report/Conference proceedingChapter


This case discusses a drug-gene interaction. Promethazine is a cytochrome P450 (CYP) 2D6 substrate. Patients who are CYP2D6 poor metabolizers exhibit greater sedation for a given promethazine dose.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Number of pages3
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • General Medicine


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