Postoperative hypopyon after intravitreal bovine thrombin for macular hole surgery

T. W. Olsen, P. Sternberg, D. F. Martin, A. Capone, J. I. Lim, T. M. Aaberg

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


PURPOSE: We used intravitreal autologous fibrinogen with bovine thrombin for the surgical closure of macular holes in 60 cases. METHODS: Pars plana vitrectomy with separation of the posterior cortical vitreous was performed after air/fluid exchange. One to two drops each of autologous fibrinogen and bovine thrombin (20 to 80 U) were instilled in each patient. RESULTS: Five (8%) of 60 patients developed a hypopyon without unusual pain on the first postoperative day. Inflammation responded to frequent topical corticosteroids within 48 to 72 hours. CONCLUSION: Postvitrectomy hypopyon after the use of bovine thrombin may represent an immune reaction that must be differentiated from endophthalmitis. We recommend careful observation and frequent topical corticosteroids.

Original languageEnglish (US)
Pages (from-to)575-577
Number of pages3
JournalAmerican journal of ophthalmology
Issue number5
StatePublished - 1996

ASJC Scopus subject areas

  • Ophthalmology


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