Porous silicon-based scaffolds for tissue engineering and other biomedical applications

Jeffery L. Coffer, Melanie A. Whitehead, Dattatri K. Nagesha, Priyabrata Mukherjee, Giridhar Akkaraju, Mihaela Totolici, Roghieh S. Saffie, Leigh T. Canham

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in the composite on in vitro calcification assays are assessed. For each system, cytotoxicity and cellular proliferation are explicitly evaluated through fibroblast cell culture assays.

Original languageEnglish (US)
Pages (from-to)1451-1455
Number of pages5
JournalPhysica Status Solidi (A) Applications and Materials Science
Issue number8
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Electrical and Electronic Engineering


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