Population screening for barrett esophagus: A prospective randomized pilot study

Joseph Y. Chang, Nicholas J. Talley, G. Richard Locke, David A. Katzka, Cathy D. Schleck, Alan R. Zinsmeister, Kelly T. Dunagan, Tsung Teh Wu, Kenneth K. Wang, Ganapathy A. Prasad

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


OBJECTIVE: To assess the feasibility of unsedated transnasal endoscopy (uTNE) and video capsule endoscopy (VCE) as alternatives to sedated endoscopy (sEGD) as screening tools for Barrett esophagus (BE) and to obtain preliminary estimates of participation rates for sEGD, uTNE, and VCE when used for community BE screening in a population cohort. PATIENTS AND METHODS: From February 1, 2009, to May 31, 2010, patients from Olmsted County, Minnesota, who were older than 50 years and had no history of known BE were randomized (stratified by age, sex, reflux symptoms noted in a validated questionnaire) into 3 groups for esophageal evaluation with sEGD, uTNE, or VCE. Participation rates and safety profiles were estimated. RESULTS : We contacted 127 patients to recruit 20 for each procedure arm (60 total). The probability of participation was 38% (95% confidence interval [CI], 26%-51%) for sEGD, 50% (95% CI, 35%-65%) for uTNE, and 59% (95% CI, 42%-74%) for VCE. Both uTNE and VCE were well tolerated without adverse effects. BE was identified in 3 patients and esophagitis in 8. CONCLUSION: Unsedated techniques may be acceptable, feasible, and safe alternatives to sEGD to screen for BE in the community. Trial Registration: clinicaltrials.gov Identifier: NCT00943280

Original languageEnglish (US)
Pages (from-to)1174-1180
Number of pages7
JournalMayo Clinic proceedings
Issue number12
StatePublished - Dec 2011

ASJC Scopus subject areas

  • General Medicine


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