Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities

V. E. Torres; P. C. Harris

doi:10.1111/j.1365-2796.2006.01743.x

Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities

V. E. Torres, P. C. Harris

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.

Original language	English (US)
Pages (from-to)	17-31
Number of pages	15
Journal	Journal of Internal Medicine
Volume	261
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2796.2006.01743.x
State	Published - Jan 2007

Keywords

Autosomal dominant polycystic kidney disease
Autosomal recessive polycystic kidney disease
ErbB tyrosine kinase inhibitors
Polycystic kidney disease
Vasopressin V2 receptor antagonists
mTOR inhibitors

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1111/j.1365-2796.2006.01743.x

Cite this

@article{eee0825c40d34044be31a81b6a8b6286,

title = "Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities",

abstract = "An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.",

keywords = "Autosomal dominant polycystic kidney disease, Autosomal recessive polycystic kidney disease, ErbB tyrosine kinase inhibitors, Polycystic kidney disease, Vasopressin V2 receptor antagonists, mTOR inhibitors",

author = "Torres, {V. E.} and Harris, {P. C.}",

year = "2007",

month = jan,

doi = "10.1111/j.1365-2796.2006.01743.x",

language = "English (US)",

volume = "261",

pages = "17--31",

journal = "Journal of Internal Medicine",

issn = "0954-6820",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Polycystic kidney disease

T2 - Genes, proteins, animal models, disease mechanisms and therapeutic opportunities

AU - Torres, V. E.

AU - Harris, P. C.

PY - 2007/1

Y1 - 2007/1

N2 - An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.

AB - An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.

KW - Autosomal dominant polycystic kidney disease

KW - Autosomal recessive polycystic kidney disease

KW - ErbB tyrosine kinase inhibitors

KW - Polycystic kidney disease

KW - Vasopressin V2 receptor antagonists

KW - mTOR inhibitors

UR - http://www.scopus.com/inward/record.url?scp=33845989853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845989853&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2796.2006.01743.x

DO - 10.1111/j.1365-2796.2006.01743.x

M3 - Article

C2 - 17222165

AN - SCOPUS:33845989853

SN - 0954-6820

VL - 261

SP - 17

EP - 31

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 1

ER -

Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this