Pneumocystis Pneumonia: Current Concepts in Pathogenesis, Diagnosis, and Treatment

Bryan J. Krajicek; Charles F. Thomas; Andrew H. Limper

doi:10.1016/j.ccm.2009.02.005

Pneumocystis Pneumonia: Current Concepts in Pathogenesis, Diagnosis, and Treatment

Bryan J. Krajicek, Charles F. Thomas, Andrew H. Limper

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Pneumocystis pneumonia (PCP) is an infection of the lungs caused by the opportunistic fungal genus Pneumocystis. In humans, PCP is a serious and potentially life-threatening infection occurring in immunocompromised individuals, particularly those who have AIDS, or following immune suppression from malignancy, organ transplantation, or therapies for inflammatory diseases. Several recent studies have contributed to understanding of the biology and pathogenesis of the organism yielding new diagnostic approaches and therapeutic targets. Although trimethoprim-sulfamethoxazole remains the mainstay of prophylaxis and treatment, ongoing concerns for emerging Pneumocystis resistance supports the continuing investigation for novel therapeutic agents.

Original language	English (US)
Pages (from-to)	265-278
Number of pages	14
Journal	Clinics in Chest Medicine
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.ccm.2009.02.005
State	Published - Jun 2009

Keywords

Acquired immunodeficiency syndrome (AIDS)
Immune suppression
Inflammation
Opportunistic infection
Pneumocystis pneumonia

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.ccm.2009.02.005

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title = "Pneumocystis Pneumonia: Current Concepts in Pathogenesis, Diagnosis, and Treatment",

abstract = "Pneumocystis pneumonia (PCP) is an infection of the lungs caused by the opportunistic fungal genus Pneumocystis. In humans, PCP is a serious and potentially life-threatening infection occurring in immunocompromised individuals, particularly those who have AIDS, or following immune suppression from malignancy, organ transplantation, or therapies for inflammatory diseases. Several recent studies have contributed to understanding of the biology and pathogenesis of the organism yielding new diagnostic approaches and therapeutic targets. Although trimethoprim-sulfamethoxazole remains the mainstay of prophylaxis and treatment, ongoing concerns for emerging Pneumocystis resistance supports the continuing investigation for novel therapeutic agents.",

keywords = "Acquired immunodeficiency syndrome (AIDS), Immune suppression, Inflammation, Opportunistic infection, Pneumocystis pneumonia",

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T2 - Current Concepts in Pathogenesis, Diagnosis, and Treatment

AU - Krajicek, Bryan J.

AU - Thomas, Charles F.

AU - Limper, Andrew H.

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N2 - Pneumocystis pneumonia (PCP) is an infection of the lungs caused by the opportunistic fungal genus Pneumocystis. In humans, PCP is a serious and potentially life-threatening infection occurring in immunocompromised individuals, particularly those who have AIDS, or following immune suppression from malignancy, organ transplantation, or therapies for inflammatory diseases. Several recent studies have contributed to understanding of the biology and pathogenesis of the organism yielding new diagnostic approaches and therapeutic targets. Although trimethoprim-sulfamethoxazole remains the mainstay of prophylaxis and treatment, ongoing concerns for emerging Pneumocystis resistance supports the continuing investigation for novel therapeutic agents.

AB - Pneumocystis pneumonia (PCP) is an infection of the lungs caused by the opportunistic fungal genus Pneumocystis. In humans, PCP is a serious and potentially life-threatening infection occurring in immunocompromised individuals, particularly those who have AIDS, or following immune suppression from malignancy, organ transplantation, or therapies for inflammatory diseases. Several recent studies have contributed to understanding of the biology and pathogenesis of the organism yielding new diagnostic approaches and therapeutic targets. Although trimethoprim-sulfamethoxazole remains the mainstay of prophylaxis and treatment, ongoing concerns for emerging Pneumocystis resistance supports the continuing investigation for novel therapeutic agents.

KW - Acquired immunodeficiency syndrome (AIDS)

KW - Immune suppression

KW - Inflammation

KW - Opportunistic infection

KW - Pneumocystis pneumonia

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Pneumocystis Pneumonia: Current Concepts in Pathogenesis, Diagnosis, and Treatment

Abstract

Keywords

ASJC Scopus subject areas

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