Plasma cell leukemia

Research output: Chapter in Book/Report/Conference proceedingChapter


Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma (MM). It is characterized by the presence of a large number of circulating clonal plasma cells. It is comprised of two forms: (1) primary PCL (pPCL) which originate de novo with no prior history of MM and (2) secondary PCL (sPCL) where patients with a prior history of MM develop a leukemic phase of their MM. The natural history of either form of PCL is quite aggressive compared with MM. The incorporation of novel agent therapies and high-dose chemotherapy followed by stem cell rescue has made modest improvement in survival outcomes of patients with PCL over the last decade. Future, clinical trials incorporating various combinations of novel and experimental therapeutics are still warranted for the management of this disease.

Original languageEnglish (US)
Title of host publicationBiology and Management of Unusual Plasma Cell Dyscrasias
PublisherSpringer New York
Number of pages16
ISBN (Electronic)9781441968487
ISBN (Print)9781441968470
StatePublished - Jan 1 2016


  • Circulating plasma cells
  • Extramedullary myeloma
  • Plasma cell leukemia

ASJC Scopus subject areas

  • General Medicine


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