Physiology of Cholngiocytes

Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F. LaRusso

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cholangiocytes are epithelial cells that line the network of interconnecting intrahepatic and extrahepatic bile ducts. The main physiologic function of cholangiocytes is the modification of the bile within the ductal lumen via coordinated bidirectional vectorial transport of ions, solutes, and water. These complex processes are regulated by extracellular signaling molecules, components of bile, and physical forces via various intracellular signaling pathways. The secretory and reabsorptive functions of cholangiocytes and the mechanisms by which these functions are regulated are reviewed in this chapter.

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract, Sixth Edition
Number of pages21
ISBN (Electronic)9780128099544
ISBN (Print)9780128124260
StatePublished - Jan 1 2018


  • Absorption
  • Biliary tree
  • Cholangiocytes
  • Ductal bile
  • Intrahepatic and extrahepatic bile ducts
  • Secretion

ASJC Scopus subject areas

  • General Medicine


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