Photodynamic therapy (PDT) with endoscopic ultrasound for the treatment of esophageal cancer

Timothy A. Woodward, Herbert C. Wolfsen

Research output: Contribution to journalConference articlepeer-review


In 1995, PDT was approved for palliative use in patients with esophageal cancer. We report our experience using PDT to treat esophageal cancer patients previously treated with combination chemotherapy and radiation therapy. In our series, nine patients referred for PDT with persistent esophageal cancer after chemo-radiation therapy. We found: (1) All patients were men with a mean age of 63 years and eight out of nine had adenocarcinoma with Barrett's esophagus; (2) All patients required endoscopic dilation after PDT; (3) At a mean follow up of 4 months, two T2N0 patients had no demonstrable tumor and all three T3N0 patients had >50% tumor reduction (the partially responsive T3N0 patients will be offered repeat PDT); (4) Patients with metastatic disease (T3N1 or M1) had effective dysphagia palliation. Thus, PDT is safe and effective in ablating all or most tumor in patients with persistent esophageal cancer after chemotherapy and radiation therapy.

Original languageEnglish (US)
Pages (from-to)422-425
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2000
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X - San Jose, CA, USA
Duration: Jan 22 2000Jan 25 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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