Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis

P. C. De Groen; D. K. McCallum; T. P. Moyer; R. H. Wiesner

Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis

P. C. De Groen, D. K. McCallum, T. P. Moyer, R. H. Wiesner

Research output: Contribution to journal › Article › peer-review

Abstract

Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.

Original language	English (US)
Pages (from-to)	509-511
Number of pages	3
Journal	Transplantation proceedings
Volume	20
Issue number	2 SUPPL. 2
State	Published - Jan 1 1988

ASJC Scopus subject areas

Surgery
Transplantation

Cite this

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title = "Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis",

abstract = "Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.",

author = "{De Groen}, {P. C.} and McCallum, {D. K.} and Moyer, {T. P.} and Wiesner, {R. H.}",

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AU - De Groen, P. C.

AU - McCallum, D. K.

AU - Moyer, T. P.

AU - Wiesner, R. H.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.

AB - Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.

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Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis

Abstract

ASJC Scopus subject areas

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