Pharmacokinetics of Agelastatin A in the central nervous system

Zhimin Li; Takuma Kamon; David A. Personett; Thomas Caulfield; John A. Copland; Takehiko Yoshimitsu; Han W. Tun

doi:10.1039/c1md00240f

Pharmacokinetics of Agelastatin A in the central nervous system

Zhimin Li, Takuma Kamon, David A. Personett, Thomas Caulfield, John A. Copland, Takehiko Yoshimitsu, Han W. Tun

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.

Original language	English (US)
Pages (from-to)	233-237
Number of pages	5
Journal	MedChemComm
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/c1md00240f
State	Published - Feb 2012

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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abstract = "Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.",

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AU - Yoshimitsu, Takehiko

AU - Tun, Han W.

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AB - Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.

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Pharmacokinetics of Agelastatin A in the central nervous system

Abstract

ASJC Scopus subject areas

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